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Summer School "Neuro-Sleep as a Complex System"
10-12 July 2023 Club "Volzhino" (link)
Venue: Saratov State University, Saratov, Russia

Speakers


The first day of the conference part 1



The first day of the conference part 2



Second day of the conference



Presentation: SLEEP EEG PATTERN IN CHILDHOOD: FROM NEWBORN TO ADOLESCENT



Felix Scholkmann
Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
“Meningeal lymphatic vessels in the human head: Examples of in vivo visualization with MRI”

In 2015, meningeal lymphatic vessels (mLVs) were (re)discovered in mice and human dura specimens. Two years later, the first report was published showing that mLVs can be detected in humans in vivo by high resolution 3 Tesla magnetic resonance imaging (MRI). In 2017 and 2018, two further studies reported the successful MRI-based detection of mLVs in vivo in humans. The aim of our study was to provide further evidence of the possibility to detect mLVs in vivo with MRI in humans. To this end, MR images already available from one subject (the first author, FS) were analyzed. We detected mLVs in the coronal plane at the bilateral superior lateral corners of the superior sagittal sinus (SSS) as well as below the SSS, in agreement with the two other published reports about the in vivo detection of mLVS in humans with MRI. Our report is thus an additional report about in vivo MR imaging of human mLVs.


Certificate: Scholkmann-certificate.pdf


Oxana Semyachkina-Glushkovskaya

Saratov State University, Saratov, Russia


"Photostimulation of the brain’s waste removal system"

Certificate: Semyachkina-Glushkovskaya.pdf


Thomas Penzel

Somnologist, Berlin, Germany


"Pathophysiology of sleep disorders"

Thomas Penzel, Prof. Dr.

Scientific Chair of the Interdisciplinary Center of Sleep Medicine

Thomas Penzel graduated from physics (1986), human biology (1991), and physiology (1995) at the University Marburg, Germany. In 2006 he moved to Berlin where he is the director of research of the Interdisciplinary Sleep Medicine Center at the Charité – Universitätsmedizin Berlin (Germany). In 2001, he received the Bial award for Clinical Medicine in Portugal, in 2008 the Bill Gruen Award for Innovations in Sleep Research by the American Sleep Research Society, and in 2014 the distinguished research award by the Chinese Sleep Research Society. He was IEEE EMBC 2019 conference chair, distinguished lecturer and is IEEE fellow. He is president of the German Sleep Society and Vicepresident-elect publications of IEEE EMBS. He is editor-in-chief of the journal Sleep and Breathing, and editorial board member of other journals. He has published 400 journal papers (Pubmed), 80 book chapters, and edited 18 books. His research interests are sleep medicine, biomedical signals, and wearables for sleep recording.

ORCHID: 0000-0002-4304-0112

https://schlafmedizin.charite.de/


Certificate: Penzel-certificate.pdf


Vladimir Salmin

National Research Nuclear University, National Research University «Moscow Institute of Physics and Technology», Bauman Moscow State Technical University, Moscow, Russia.


“Fluorescence spectroscopy for brain research”

Professor Vladimir V. Salmin, PhD, Dr.Sci.

National Research University «Moscow Institute of Physics and Technology» (MIPT), (Moscow, Russia), National Research Nuclear University (MEPHI), (Moscow, Russia), Bauman Moscow State Technical University (BMSTU), (Moscow, Russia)

There are numerous methods of optical diagnostics in biological objects, incl. fluorescence spectroscopy in vivo. Minimally invasive and non-invasive optical methods are often used for the assessment of tissue hypoxia, inflammation, and metabolic alterations. In the brain, autofluorescence spectroscopy provides information on energy metabolism, accumulation of advanced glycation end products, cell-to-cell communication, changes in intracranial tension, development of hypoxia and ischemia, blood-brain barrier breakdown, pharmacokinetic and pharmacodynamic effects of drugs.


Certificate: Salmin-certificate-2023.pdf


Tingting YU

Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology (HUST)


Tissue Optical Clearing for Whole-Organ Imaging

Her research interests are focused on tissue optical clearing methods and applications. In recent years, she has studied the mechanisms of tissue optical clearing and has developed differet ex vivo clearing techniques for acquiring and reconstructing three-dimensional structural information of the central nervous system, peripheral nervous system, and other tissues or organs. As a first or corresponding author, she has published over 20 SCI papers in journals including Nature Communications, Science Advances, Theranostics, and others, as well as in the book (Handbook of Tissue Optical Clearing: New Prospects in Optical Imaging, 2022, CRC press). She also has 5 patents for inventions or utility models. She is also a member of the Youth Committee of the Biomedical Photonics Division of the Chinese Society of Biomedical Engineering and a member of the Youth Committee of Biomedical Photonics of the Chinese Optical Society.


Certificate: Tingting_s.pdf


Evgeny Verbitsky

Federal Research Center Southern Scientific Center of the Russian Academy of Sciences, Rostov on Don, Russia


The active environment of the brain and sleep

PhD, ScD, Professor, Chief Researcher of the Lab. Ecology, Head of the Rostov branch of the Russian Society of Somnologists, Head of the Rostov branch of the Physiological Society of the Russian Academy of Sciences


Certificate: Verbitsky-certificate-2023.pdf


Maria Farsari

Laser Division, Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology-Hellas (FORTH, Greece)


Laser-based 3D printing for Biomedical Applications

“Laser-Based additive manufacturing for biomedical applications”


Certificate: Farsari-certificate.pdf


Madaeva Irina
Irkutsk Somnological Center, Irkutsk, Russia
“Sleep EEG and aging”

MD, PhD, ScD, Head of the Irkutsk Somnological Center, chief researcher of the Laboratory of Somnology and Neurophysiology . Scientific and practical interest : sleep apnea and sleep disorders in various age, gender and ethnic groups, search for molecular and cellular biomarkers and EEG patterns. Currently , the scientific research of I.M. Madaeva is focused on the search for individual brain correlates of accelerated brain aging in sleep disorders.


Certificate: Madaeva-certificate-2023.pdf


Liudmila Yakubova
Grodno Medical University, Grodno, Belarus
“Can a lack of sleep cause high blood pressure?”

Head of the Department of General Medical Practice and Polyclinic Therapy

Grodno State Medical University, Grodno, Belarus

«Can a lack of sleep cause high blood pressure?»

The purpose of my report was to present research data on the relationship between sleep disorders and high blood pressure.

Globally - the duration of night sleep has decreased (WHO). J. Gangwisch et al. (2006), who showed that a sleep duration of less than 5 hours increases the risk of developing hypertension by 60%. ARIC study showed, that participants who complained of difficulty falling asleep or sleep incontinence had a higher risk of developing hypertension at the end of the 6-year follow-up period (RR=1.2; 95% CI 1.03–1.3). Chronic sleep disorders are accompanied by an increase in catecholamine levels and activation of the nerves of the sympathetic nervous system, contributing to an increase in BP. But, excessive sleep is also not harmless to the body, and hypertension is observed more often in those people whose sleep lasts more than 9 hours, compared with those who sleep 7–8 hours a day (the Sleep Heart Health Study). On the other hand, the frequency of hypertension in patients with insomnia ranges from 21.4 to 50.2%, while in patients without insomnia it ranges from 11.0 to 41.8%.

Thus, more research is needed to evaluate pathophysiological relationships between lack of sleep and hypertension for the answer the question: what comes first?


Certificate: Yakubova-certificate-2023.pdf


Alla Salmina

Research Center of Neurology, Moscow, Russia


“Brain plasticity: from subcellular organelles to multicellular ensembles”

Professor Alla B. Salmina, MD, PhD, Dr.Med.Sci.

Brain Science Institute, Research Center of Neurology (Moscow, Russia); N.E. Bauman Moscow State Technical University (Moscow, Russia); Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University (Krasnoyarsk, Russia)

Brain plasticity is a phenomenon underlying key mechanisms of brain activity. Synaptic transmission, synapse turnover, neurite outgrowth, changes in gene expression, induction of angiogenesis and neurogenesis contribute to short-term and long-term events induced by external stimuli, incl. learning and memory. Metabolic activity of cells within the neurovascular unit supports brain plasticity and provides effective functional coupling of cells within multicellular ensembles. Sleep affects brain plasticity in various ways: repair of DNA double-strand breaks caused by the expression of immediate early genes in pre-activated neurons, adjusting the synaptic strength to the needs of the next day, synchronization of neuronal activity, changes in mitochondrial dynamics and energy production in brain cells, promotion of neurogenesis for efficient memory consolidation, reversible changes in the permeability of brain barriers leading to optimization of brain fluids dynamics.


Certificate: Salmina-certificate-2023.pdf


Vladimir M. Kovalzon

Ph.D. Engaged in the experimental sleep research for more than 50 years. Published more than 200 papers, including severaL books (in Russian): "Basics of Somnology" (2011), "Sleep Pendulum" (2021), etc.




Certificate:


Vladimir Dorokhov

Laboratory of Neurobiology of sleep and wake, Institute of Higher Nervous Activity and Neurophysiology, Russia Academy of Sience, Russia


“K-complexes as a marker of working memory activation during sleep upon restoration of disturbed activity”

Institute of Higher Nervous Activity &Neurophysiology RAS. Butlerov 5A, 117485 Moscow, Russia

K - complexes as a marker of working memory during sleep upon restoration disturbed activity

K - complexes as a marker of working memory (WM) during sleep upon restoration disturbed activity. In order to prove the possibility of extracting information from WM during sleep, the experiment must be constructed is used when waking up. We have developed such a form of experiment in the form of continuous psychomotor activity, the monotonous nature of which quickly caused short-term episodes of falling asleep, followed by spontaneous awakening.

We have shown that spontaneous recovery of psychomotor activity after short-term episodes of sleep, with an EEG picture of the 2 stage of sleep, is accompanied by the appearance of EEG patterns in the form of a K-complex. Statistical analysis showed a significant increase in the probability of the appearance of the K-complex before the moment of awakening.

In the background, after the appearance of K-complexes almost the same EEG as before the appearance of K-complexes. In the case of the appearance of K-complexes before pressing the pedal high-amplitude forms of EEG and alpha rhythm appear before pressing the pedal


Certificate: Dorokhov-certificate-2023.pdf


Jürgen Kurths

Humboldt University, Berlin; Potsdam Institute for Climate Impact Research, Potsdam, Germany


Complex Networks: A Universal Approach in Physiology?

Certificate: Jürgen-certificate.pdf


Li Dongyu

Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology (HUST), Tissue Optical Clearing for Whole-Organ Imaging


A Through-Intact-Skull (TIS) chronic window technique for cortical structure and function observation in mice.

Certificate: Li-certificate.pdf


Sergey Sokolosky

Aston University, Birmingham, England


“Photonic approaches in modulation of the neural cells: brain and cell culture”

Nano-printed 3D scaffolds opened a new era in three-dimensional functional tissue engineering. Laser-based nano-scale biomaterial printing technique makes possible customised cell growth supporting scaffolds of required architecture. Consequent three EU funded research projects gave us opportunity to develop technologies for 3D neuronal cells networking cultures (MESO_BRAIN and Scaffolds-Need), and sensor-skin and motor-muscle models (PLATFORMA). The results partially published prove that human stem cell and laser 3D-printing technologies together enable developments of different functional 3D tissue engineering for biomedical and cosmetic applications.


Certificate: Sokolosky-certificate.pdf


Teemu Myllylä

University of Oulu, Oulu, Finland


“fNIRS studies on human sleep”

The Glymphometer is an easy-to-use wearable brain monitoring device, aiming to measure relevant parameters for diagnostics of glymphatic function and its possible abnormalities. Currently in development, the headband-based device can be used for continuous brain monitoring, both during awake and sleep. The main modalities of the device are multiwavelength functional near-infrared spectroscopy (fNIRS) and direct current electroencephalography (DC EEG) for measurement of neurohydrodynamics.


Certificate: Myllylä-certificate.pdf